Does Pregabalin Show Up on a Drug Test?
Many people wonder if pregabalin (often known by the brand name Lyrica) shows up on a drug test. This question comes up for patients, people with mental health concerns, and those worried about substance abuse. In this article, we will explain in simple words how drug tests work, what pregabalin is, and what you need to know if you take this medication.

What Is Pregabalin?
Pregabalin is a medication that helps people with pain, seizure, anxiety, and epilepsy. Doctors often give it to patients who have:
- Diabetic neuropathy (nerve pain from diabetes)
- Pain from spinal cord injury
- Seizure problems
- Some kinds of mental health issues like anxiety
It works by calming overactive nerves in your body. Pregabalin belongs to a group of medicines called anticonvulsant drugs. These drugs can help with seizures and pain.
Does Pregabalin Show Up on a Drug Test?
A drug test checks urine, blood, or saliva for drugs. Common tests look for opioids, narcotic pain pills, alcohol, and other drugs. Pregabalin is a controlled substance under the Controlled Substances Act. However, it is not always part of a normal urine test or blood plasma drug panel.
This means:
- Standard tests for jobs may not test for pregabalin.
- Special lab tests can find it if the doctor orders it.

How Long Does Pregabalin Stay in Your Body?
Pregabalin has an active ingredient that leaves your body through your urine. Doctors say most of the drug leaves within 1–2 days. In some blood or urine test, it may be found for a short time after you stop taking it.
Factors that change this include:
- The dose you take
- Your health
- If you take other medication like tramadol, duloxetine, or venlafaxine
Types of Drug Tests and Pregabalin
Urine Drug Test
Pregabalin is easiest to find in a urine test. If someone is looking for pregabalin, the lab can find it.
Blood Drug Test
Some doctors order blood plasma testing to check levels of the drug.
Saliva Drug Test
Pregabalin does not show up well in saliva tests. It is less common to test for it this way.
Why Might a Doctor Test for Pregabalin?
Doctors may test for pregabalin if:
- A patient shows signs of addiction
- There are concerns about substance abuse
- A person has dual diagnosis (mental health problems and drug misuse)
They may also test when a person is having side effects like headache, insomnia, poor concentration, or lyrica withdrawal symptoms.
Pregabalin and the Controlled Substances Act
Pregabalin is a controlled substance because it has some risk for addiction. The Food and Drug Administration (FDA) and the Controlled Substances Act both watch over this drug.
Can Pregabalin Be Addictive?
Yes. Even though it is not an opioid, pregabalin can lead to addiction in some people. Using it with alcohol, oxycodone, fentanyl, or other narcotic pain drugs can be very dangerous.
Conditions Pregabalin Treats
Doctors use pregabalin for:
- Epilepsy and seizure control
- Diabetic neuropathy pain
- Spinal cord injury pain
- Anxiety disorders in some patients
- It is sometimes used with therapy to help with mental health problems
Does Pregabalin Interact With Other Drugs?
Pregabalin can interact with:
- Tramadol
- Oxycodone
- Fentanyl
- Methylphenidate
- Duloxetine
- Venlafaxine
These combinations can raise the risk of side effects, including addiction or trouble breathing.

Lyrica Withdrawal and Drug Testing
If a patient stops pregabalin suddenly, they may have lyrica withdrawal symptoms such as headache, insomnia, anxiety, and poor concentration. This is why doctors may test blood or urine levels to make sure the medication is taken as prescribed.
Insurance and Drug Testing
Some insurance plans cover drug tests if your doctor thinks it is needed. This might be for a disease like epilepsy or for monitoring addiction treatment.
Pregabalin Is Not an Opioid
It is important to know pregabalin is not an opioid. It is an anticonvulsant, but because it can be misused, it is listed as a controlled substance.
Pregabalin and Mental Health
People with mental health conditions may need special care when using pregabalin. If there is a dual diagnosis (both mental illness and drug misuse), the doctor may monitor more closely with drug tests.
Therapy and Support
Therapy and counseling can help people who worry about substance abuse. If pregabalin is part of treatment, it should be taken as the doctor says. Mixing it with alcohol or other drug like fentanyl or oxycodone can be harmful.
Final Thoughts
So, does pregabalin show up on a drug test? The answer is yes, if the test looks for it. Normal workplace tests do not always check for it. If you are a patient taking pregabalin, always talk to your doctor about any drug test. This way you can give the right information about your dose and medication.

FAQs
Does pregabalin show up on a urine drug test?
Pregabalin can show up on a urine test if the lab is looking for it. Regular tests may not include it.
Does pregabalin show up on a blood drug test?
Yes, blood plasma tests can detect pregabalin for a short time.
Does pregabalin show up on a saliva drug test?
Pregabalin does not show up well in saliva drug tests. This is not a common way to test for it.
Is pregabalin a narcotic drug?
No, pregabalin is not a narcotic. It is an anticonvulsant. But it is a controlled substance.
Can pregabalin cause addiction?
Yes, there is a risk of addiction, especially when mixed with alcohol, opioids, or other drugs.