ETG (Ethyl Glucuronide): A direct metabolite of ethanol (alcohol), ETG is used to detect recent alcohol consumption up to 80 hours after ingestion.
ETS (Ethyl Sulfate): Another alcohol metabolite used to confirm recent ethanol intake, typically used in conjunction with ETG for accuracy.
Alkaloids
7-Hydroxymitragynine (Kratom): An active metabolite of mitragynine, found in Kratom, a Southeast Asian plant with opioid-like effects. Street names: Krypton, Thang.
Cotinine (Nicotine): A metabolite of nicotine, used to verify tobacco use. Commonly found in smokers and users of nicotine replacement products.
Kavain: A compound found in the Kava plant, used for its sedative and anxiolytic effects. Not widely used recreationally but included in herbal supplements.
Phenibut: A central nervous system depressant used to treat anxiety and insomnia in some countries. Street names: Noofen, Party Powder.
Amphetamines
Amphetamine: A stimulant affecting the central nervous system, found in ADHD medications like Adderall. Street names: Speed, Uppers.
Methamphetamine: A powerful, highly addictive stimulant with limited medical use. Street names: Crystal, Ice, Meth.
Phentermine: A stimulant used as an appetite suppressant for weight loss. Brand names: Adipex-P, Lomaira.
Anticonvulsants
Gabapentin: Used to treat nerve pain and seizures; often misused for its sedative effects. Brand name: Neurontin.
Pregabalin: Similar to gabapentin; used for nerve pain, seizures, and anxiety. Brand name: Lyrica.
Antidepressants
Amitriptyline: A tricyclic antidepressant used for depression and chronic pain. Brand name: Elavil.
Desipramine: Another tricyclic antidepressant. Brand name: Norpramin.
Duloxetine: A serotonin-norepinephrine reuptake inhibitor (SNRI) used for depression and fibromyalgia. Brand name: Cymbalta.
Fluoxetine: A selective serotonin reuptake inhibitor (SSRI) used for depression. Brand name: Prozac.
Hydroxybupropion: An active metabolite of bupropion, used for depression and smoking cessation. Brand name: Wellbutrin.
Nortriptyline: Tricyclic antidepressant also used for chronic pain. Brand name: Pamelor.
O-desmethylvenlafaxine: Active metabolite of venlafaxine. Brand name: Pristiq.
Paroxetine: SSRI used for depression and anxiety. Brand name: Paxil.
Sertraline: SSRI for depression, anxiety, and PTSD. Brand name: Zoloft.
Tianeptine: Atypical antidepressant with opioid activity; sometimes abused. Street name: Zaza.
Trazodone: Antidepressant often used off-label for sleep. Brand name: Desyrel.
Venlafaxine: SNRI used for depression and anxiety. Brand name: Effexor.
Antipsychotics
9-hydroxyrisperidone: Active metabolite of risperidone. Brand name: Risperdal.
Dehydroaripiprazole: Metabolite of aripiprazole. Brand name: Abilify.
Norquetiapine: Metabolite of quetiapine. Brand name: Seroquel.
Barbiturates
Butalbital: Used in combination headache medications. Brand names: Fioricet, Fiorinal.
Phenobarbital: Long-acting barbiturate used for seizures and sedation.
Benzodiazepines
7-Amino Clonazepam: Metabolite of clonazepam. Brand name: Klonopin.
Alpha Hydroxyalprazolam: Metabolite of alprazolam. Brand name: Xanax.
Alprazolam: Benzodiazepine used for anxiety. Street name: Bars, Xannies.
Bromazolam: Novel benzodiazepine; not approved for medical use. Sometimes sold illicitly online.
Etizolam: Thienodiazepine with benzodiazepine-like effects. Street name: Etiz
Lorazepam: Used for anxiety and acute seizures. Brand name: Ativan.
Nordiazepam: Metabolite of several benzos like diazepam. Brand name: Librium (related).
Oxazepam: Used for anxiety and alcohol withdrawal. Brand name: Serax.
Temazepam: Used for insomnia. Brand name: Restoril.
Buprenorphine
Buprenorphine: Partial opioid agonist used for opioid addiction treatment. Brand names: Suboxone (with naloxone), Subutex.
Norbuprenorphine: Active metabolite of buprenorphine.
Cannabinoids
7-hydroxy-CBD: Metabolite of cannabidiol (CBD), non-psychoactive component of cannabis.
THC-COOH: Main metabolite of THC, the psychoactive component in marijuana. Street names: Weed, Pot.
Cocaine
Benzoylecgonine: Primary metabolite of cocaine. Street names: Coke, Blow.
Cough Medicine
Dextrorphan: Metabolite of dextromethorphan (DXM), found in OTC cough meds. Street names: Robo, Skittles.
Ecstasy
MDMA: Synthetic stimulant and hallucinogen. Street names: Ecstasy, Molly.
Fentanyl
Carfentanil: Extremely potent fentanyl analog, used for veterinary purposes. Dangerous in humans.
Fentanyl: Synthetic opioid, 50–100 times more potent than morphine. Street names: China White, Apache.
Norfentanyl: Metabolite of fentanyl.
Heroin
6-Acetylmorphine: Unique metabolite of heroin, confirming its use. Street names: Smack, H.
Illicit
2-oxo-3-hydroxy-LSD: LSD metabolite, confirming hallucinogen use. Street names: Acid, Tabs.
Ketamine
Ketamine: Dissociative anesthetic used in medicine and abused recreationally. Street names: Special K, K.
Norketamine: Active metabolite of ketamine.
Kratom (Mitragynine)
Mitragynine: Active alkaloid in Kratom. Street names: Biak-biak, Ketum.
Methadone
EDDP: Metabolite of methadone.
Methadone: Synthetic opioid used for pain and addiction treatment. Brand names: Dolophine, Methadose.
Methylphenidate
Ritalinic acid: Metabolite of methylphenidate. Brand names: Ritalin, Concerta.
Muscle Relaxants
Carisoprodol: Muscle relaxant with sedative properties. Brand name: Soma.
Cyclobenzaprine: Used for muscle spasms. Brand name: Flexeril.
Meprobamate: Metabolite of carisoprodol; also a sedative.
Opiates/Opioids
4-hydroxyxylazine: Metabolite of xylazine, a veterinary sedative increasingly found in street drugs.
Codeine: Opioid used for pain and cough. Brand name: Tylenol #3.
Hydrocodone: Opioid pain medication. Brand names: Vicodin, Norco.
Hydromorphone: Potent opioid for severe pain. Brand name: Dilaudid.
Meperidine: Synthetic opioid. Brand name: Demerol.
Morphine: Classic opioid pain medication. Street name: M.
Naloxone: Opioid antagonist used to reverse overdoses. Brand name: Narcan.
Naltrexone: Opioid antagonist used to treat addiction. Brand names: Vivitrol, Revia.
Normeperidine: Metabolite of meperidine.
Oxycodone
Oxycodone: Semi-synthetic opioid. Brand names: OxyContin, Percocet.
Oxymorphone: Metabolite of oxycodone. Brand name: Opana.
Phencyclidine
PCP: Dissociative hallucinogen. Street names: Angel Dust, Peace Pill.
Psilocin: The active chemical in magic mushrooms that causes hallucinations
Psilocin
Sedative/Hypnotic
Zaleplon: Non-benzodiazepine sedative. Brand name: Sonata.
Zolpidem: Sedative used for insomnia. Brand name: Ambien.
Zolpidem Phenyl-4-carboxylic acid: Metabolite of zolpidem.
Dexmedetomidine: Sedative often used in ICUs. Brand name: Precedex.
Synthetic Stimulants
Alpha PVP: Synthetic stimulant. Street name: Flakka.
Eutylone: Cathinone class stimulant. Street names: Bath Salts, E.
MDPV: Powerful stimulant. Street name: Super Coke.
Mephedrone: Synthetic stimulant. Street names: Meph, Drone.
Methylone: MDMA analog. Street names: Explosion, Molly.
N,N-Dimethylpentylone: New synthetic stimulant found in designer drugs.
Tapentadol
Tapentadol: Dual-action opioid and norepinephrine reuptake inhibitor for pain. Brand name: Nucynta.
Tramadol
O-Desmethyltramadol: Active metabolite of tramadol.
Tramadol: Weak opioid used for moderate pain. Brand names: Ultram, ConZip
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