How To Get Rid Of Cotinine From Your Blood Fast

woman smoking

How To Get Rid Of Cotinine From Your System Blood

If you’re trying to get rid of cotinine from your system and blood, you’re not alone. Many people want to feel better, pass a blood test, or improve their health. Cotinine is a metabolite of nicotine. That means it’s what’s left in your body after using nicotine from things like tobacco smoke or vapes.

Whether you’re quitting smoking, worried about a drug test, or just want to live a healthier lifestyle, this guide will help you understand what cotinine is, how it affects your body, and how to flush it out of your system.

How To Get Rid Of Cotinine

What Is Cotinine?

Cotinine is a chemical your body makes after it breaks down nicotine. It can stay in your blood, saliva, urine, and even hair. Doctors and labs use it as a biomarker to see if someone has used tobacco.

If you breathe in passive smoking (also called secondhand smoke), cotinine can still show up in your body. Even small doses from aerosol (vape clouds) may leave cotinine behind.

How Long Does Cotinine Stay In Your System?

How long cotinine stays depends on:

  • Your age

  • Your body mass index

  • Your liver health

  • How often you smoke or are exposed to tobacco smoke

Here’s a rough idea:

  • Blood test: Cotinine stays up to 10 days

  • Saliva testing: Can detect cotinine for 4–7 days

  • Urine test: Cotinine may stay 3–4 days, sometimes longer

  • Hair: Cotinine can stay for months

The Centers for Disease Control and Prevention (CDC) tracks these levels through biomonitoring research.

Getting rid of nicotine tobacco

Why Is Cotinine Harmful?

Having cotinine in your body means you’ve been exposed to nicotine, a strong stimulant. This can lead to problems like:

  • High blood pressure

  • Heart rate changes

  • Anxiety, stress, and insomnia

  • Risk of lung cancer, breast cancer, and cardiovascular disease

  • Headaches, migraines, and nausea

  • Issues like asthma, cough, and fatigue

  • More serious conditions like chronic obstructive pulmonary disease (COPD)

The American Lung Association and American Cancer Society warn about the risks linked to tobacco and cotinine.

How To Remove Cotinine From Your Blood

Now let’s talk about what you can do to detox cotinine from your system.

Drink More Water

Drinking water helps your body flush out toxins, including cotinine. Water cleans your blood, liver, and urine. Aim for 8–10 glasses each day to speed up detox.

Eat Detox-Friendly Foods

Certain foods help the detoxification process:

  • Broccoli and garlic: boost liver enzymes

  • Vitamin-rich fruits and vegetables: fight oxidative stress

  • Antioxidants: help repair cell damage

  • High-fiber meals: help remove toxins through digestion

Try to avoid sugar, fried food, and soda while you’re detoxing.

Exercise Every Day

When you exercise, your body sweats out toxins. It also boosts dopamine and helps with mood, stress, and appetite. Plus, staying active can improve your sleep and help with weight control.

Try walking, biking, or even dancing. Exercise can help with:

  • Blood pressure

  • Heart health

  • Clearing out your system

Get Plenty of Sleep

Sleep helps your brain, body, and organs heal. It also supports liver and kidney functions. Aim for 7–9 hours each night.

Not sleeping enough can cause:

  • Insomnia

  • Fatigue

  • Slower detox

  • More anxiety or bipolar disorder symptoms

Quit Tobacco and Nicotine

The only real way to stop cotinine from building up is to quit smoking or using any form of nicotine.

Try methods like:

  • Cold turkey (quitting all at once)

  • Varenicline or nicotine replacement

  • Counseling from your primary care doctor or registered nurse

  • Join a substance abuse program if you’re struggling

Some people also try tools like:

  • Semaglutide for weight and craving support

  • Inhalers or nicotine patches

  • Medicine from a physician

If you’re pregnant or breastfeeding (breast milk), quitting nicotine is even more important to protect your baby.

Use Natural Supplements

Some people take vitamins or supplements for detox. Talk to a health care provider before starting anything new.

Helpful options may include:

  • Vitamin C

  • Green tea (a natural antioxidant)

  • Liver support herbs

Manage Side Effects

Detoxing from nicotine and cotinine may cause side effects like:

  • Headache

  • Migraine

  • Diarrhea or constipation

  • Stress and anxiety

  • Appetite changes

  • Trouble sleeping

Know that these are normal, and they don’t last forever. Stay hydrated, eat well, and ask for help if needed.

When To See a Doctor

Talk to your physician or primary care provider if:

  • You have a medical condition like diabetes, ulcerative colitis, or type 2 diabetes

  • You’ve had organ transplantation

  • You take meds like adderall

  • You’re worried about blood pressure or heart rate

  • You’re going through withdrawal

Doctors may do a blood test, saliva testing, or urine test to check your reference range for cotinine.

The Food and Drug Administration (FDA) and National Cancer Institute offer trusted information on the health risks of tobacco.

How Cotinine Affects Mental Health

Cotinine and nicotine also affect the brain. People who smoke may feel pleasure at first, but then deal with:

  • Anxiety

  • Depression

  • Bipolar disorder

  • Stress and poor sleep

Over time, using nicotine to cope can lead to addiction and substance abuse.

If this sounds like you or a loved one, talk to a mental health provider.

How Passive Smoking Impacts Others

Even if you don’t smoke, being around someone who does can put cotinine in your body. This is called passive smoking. It’s especially risky for:

  • Children

  • Pregnant women

  • People with asthma or lung disease

  • People with psoriasis or multiple sclerosis

There’s research that shows secondhand smoke raises the risk of cancer, diabetes, and cardiovascular disease.

What Organizations Say About Cotinine

  • The Centers for Disease Control and Prevention (CDC) warns about cotinine in smokers and non-smokers.

  • The American Cancer Society promotes tobacco control and abstinence to prevent disease.

  • The American Lung Association educates the public about lung health.

  • The National Cancer Institute supports research on how cotinine impacts cancer risk.

These trusted groups encourage people to quit, detox, and stay healthy.

Helpful Lifestyle Tips

  • Keep a healthy meal plan

  • Avoid triggers like coffee or alcohol

  • Cut back on drinking sugary or caffeinated drinks

  • Try calming activities to lower stress

  • Talk to a counselor if quitting is hard

person breaking smoking habits

How Long Until Cotinine Leaves My Body?

It depends on your habit, dose, and health. With abstinence and detox tips like drinking water, eating right, and exercise, most people can clear cotinine in 7–10 days.

In people who continue smoking, levels may stay high for weeks or months.

Frequently Asked Questions

1. How does cotinine get into my blood?
Cotinine gets into your blood after you use nicotine. This includes tobacco smoke, vapes, or even being around passive smoking.
Drink lots of water, eat detox foods like broccoli, exercise, and quit using nicotine. Talk to a registered nurse or physician if needed.
Yes. A drug test, blood test, urine test, or saliva testing can show cotinine. It’s often used as a biomarker for smoking or nicotine use.
You might feel nausea, fatigue, headache, or stress. These are normal and usually go away in a few days. Stay hydrated and eat healthy meals.
Yes. Cotinine and nicotine affect dopamine, mood, and mental health. They can make anxiety, depression, and bipolar disorder worse over time.
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Medically Reviewed By Zachary Steel

Zach Steel is a diagnostics entrepreneur focused on making testing faster, more accessible, and actionable.

Written By Kristina Westerdahl

With a background in cellular molecular biology and law, Kristina’s expertise bridges science and advocacy.

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